Negative regulation of cells proliferation by Gax gene and its mechanisms].

Laboratory of Cellular and Molecular Biology, Institute of Integrated Traditional Chinese and Western Medicine, Affiliated Huashan Hospital, Fudan University, Shanghai 200040, China.

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 2009 Feb

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Gax gene is a newly found negative transcriptional regulator of cells proliferation. This paper introduces the detection and structural features of Gax, details the inhibitory effect of Gax on the proliferation of vascular smooth muscle cells, vascular endothelial cells and cancer cells, and explains the putative mechanisms therein involved. The potential for providing therapeutic insights into human diseases by modulating Gax activity is prospected.

Citation

Shijin Xia, Xiantao Tai, Guisheng Qian. Negative regulation of cells proliferation by Gax gene and its mechanisms]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. 2009 Feb;26(1):206-10