Identification of Ecl family genes that extend chronological lifespan in fission yeast.

Hokuto Ohtsuka, Yuki Ogawa, Hiroyuki Mizuno, Satoka Mita, Hirofumi Aiba

Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.

Bioscience, biotechnology, and biochemistry 2009 Apr 23

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In fission yeast, we identified two genes, named ecl2+ and ecl3+, that are paralogous to ecl1+, which extends the chronological lifespan. Both ecl2+ and ecl3+ extend the chronological lifespan when overexpressed as ecl1+. ecl2+ and ecl3+ encode 84- and 89-amino acid polypeptides respectively that are not annotated in the current database. The Ecl2 protein is localized mainly in the nucleus, as Ecl1. These results suggest that ecl1+, ecl2+, and ecl3+ have overlapping functions in the regulation of chronological lifespan.

Citation

Hokuto Ohtsuka, Yuki Ogawa, Hiroyuki Mizuno, Satoka Mita, Hirofumi Aiba. Identification of Ecl family genes that extend chronological lifespan in fission yeast. Bioscience, biotechnology, and biochemistry. 2009 Apr 23;73(4):885-9