Coal dust contiguity-induced changes in the concentration of TNF-alpha and NF-kappa B p65 on the ocular surface.

Zhaoyi Sun, Jing Hong, Zaiying Liu, Xiudong Jin, Changhong Gu

Department of Ophthalmology, First Affiliated Hospital of China Medical University, Shenyang, China.

Ocular immunology and inflammation 2009 Mar-Apr

filter terms:

To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF-alpha and NF-kappa Bp65 and dry eye occurrence. Tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Expression TNF-alpha and NF-kappa Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF-kappa B p65 and TNF-alpha perhaps as a mechanism to resist coal dust ocular surface injury.

Citation

Zhaoyi Sun, Jing Hong, Zaiying Liu, Xiudong Jin, Changhong Gu. Coal dust contiguity-induced changes in the concentration of TNF-alpha and NF-kappa B p65 on the ocular surface. Ocular immunology and inflammation. 2009 Mar-Apr;17(2):76-82