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Severe combined immunodeficiency (SCID) often presents with mucosal infections, cutaneous infections and eczematous rashes. We present two patients with history of SCID diagnosed at an early age who experienced diffuse dyschromia associated with their bone marrow and stem cell transplants. Dyschromias may be caused by numerous factors including medications, genetics, environmental contacts, or as a sequela of underlying chronic disease. These case reports describe progressive repigmentation to original skin color after the occurrence of dyschromia in two patients with SCID.


Candrice R Heath, Cynthia J Burk, Leslie P Lawley, Anthony J Mancini, Elizabeth Alvarez Connelly. Severe combined immunodeficiency (SCID)-associated dyschromia with subsequent repigmentation: a report of two patients. Pediatric dermatology. 2009 Mar-Apr;26(2):162-8

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PMID: 19419463

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