Rhinofacial conidiobolomycosis caused by Conidiobolus coronatus in a Chinese rice farmer.

Xiumin Yang, Yadi Li, Xiaoqian Zhou, Yuxin Wang, Suying Geng, Honggang Liu, Qingwen Yang, Xinxin Lu, Masataro Hiruma, Takashi Sugita, Shigaku Ikeda, Hideoki Ogawa

Mycoses 2010 Jul

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We provide the first report of rhinofacial conidiobolomycosis caused by Conidiobolus coronatus in China. The patient was a 36-year-old male rice farmer from Jiang Xi province who presented with diffuse swelling with classical centrofacial distribution and involvement of the right paranasal sinuses. Histopathology showed granulomas with hyphae surrounded by an eosinophilic sheath (Splendore-Hoeppli phenomenon). Culture of biopsy specimens on Sabouraud's dextrose agar led to the growth of fungi with microscopically visible conidiophores and terminal spherical conidia (primary conidium), with multiple secondary conidia and villose conidia. The patient was successfully treated with combination therapy, primarily itraconazole and terbinafine. We conclude with a brief literature review of the epidemiology of conidiobolomycosis.

Citation

Xiumin Yang, Yadi Li, Xiaoqian Zhou, Yuxin Wang, Suying Geng, Honggang Liu, Qingwen Yang, Xinxin Lu, Masataro Hiruma, Takashi Sugita, Shigaku Ikeda, Hideoki Ogawa. Rhinofacial conidiobolomycosis caused by Conidiobolus coronatus in a Chinese rice farmer. Mycoses. 2010 Jul;53(4):369-73