Purine uptake in Plasmodium: transport versus metabolism.

Kiaran Kirk, Susan M Howitt, Stefan Bröer, Kevin J Saliba, Megan J Downie

Biochemistry and Molecular Biology, School of Biology, The Australian National University, Canberra ACT 0200, Australia. kiaran.kirk@anu.edu.au

Trends in parasitology 2009 Jun

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In a recent paper, Quashie et al. have proposed that purine uptake into the intraerythrocytic malaria parasite involves four different plasma membrane transporters - two high affinity and two low affinity. They equate one of the two high-affinity transporters with PfNT1, a transporter reported previously to be a low-affinity system. Here, we offer an alternative interpretation of their data, suggesting that the conclusions drawn by Quashie et al. take insufficient account of metabolism.

Citation

Kiaran Kirk, Susan M Howitt, Stefan Bröer, Kevin J Saliba, Megan J Downie. Purine uptake in Plasmodium: transport versus metabolism. Trends in parasitology. 2009 Jun;25(6):246-9