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As with vincristine, intrathecal injection of vindesine can cause fatal or irreversible neurological lesions. In addition to adopting treatment protocols designed to keep intravenous and intrathecal administration totally separate, intravenous vindesine should be used exclusively after dilution in sufficiently large infusion bags.
Citation
Death due to intrathecal vindesine. Prescrire international. 2008 Aug;17(96):153
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PMID: 19492486
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