Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)].

Zhixin Chen, Min Chang, Yali Peng, Li Zhao, Yurui Zhan, Lijing Wang, Rui Wang

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, PR China.

Protein and peptide letters 2009

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In neonatal rat metatarsal organ culture, a bell-shaped dose-related curve in length of mineralized area, increases in the height of proliferative and hypertrophic zones, in the number of hypertrophic chondrocyte and in the amount of Runx2 mRNA, were revealed after treatment with OGP(10-14). We conclude that OGP(10-14) accelerates bone growth.

Citation

Zhixin Chen, Min Chang, Yali Peng, Li Zhao, Yurui Zhan, Lijing Wang, Rui Wang. Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)]. Protein and peptide letters. 2009;16(9):1074-80