Markedly elevated serum alkaline phosphatase level in an uncomplicated pregnancy.

In normal pregnancy, although maternal serum alkaline phosphatase increases and reaches the two-fold of non-pregnant serum level, above this level, hepatic, renal, osteal diseases and malignancies should be kept in mind. We report a case of 28-year-old pregnant woman with increased maternal serum level of alkaline phosphatase activity (17-fold) due to an increased level of placental isozyme. She delivered vaginally a healthy female baby. After delivery, maternal serum alkaline phosphatase activity returned to normal reference range. The aim of this case report is to show this exaggerated isozyme activity of alkaline phosphatase in pregnancy, and to differentiate it from other causes of elevated level of alkaline phosphatase.

Citation

Handan Celik, Midraci Tosun, Mehmet Bilge Cetinkaya, Ahmet Bektab, Erdal Malatyalýodlu. Markedly elevated serum alkaline phosphatase level in an uncomplicated pregnancy. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2009 Aug;22(8):705-7

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PMID: 19544151

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