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Indolmycin, a potential antibacterial drug, competitively inhibits bacterial tryptophanyl-tRNA synthetases. An effort to identify indolmycin resistance genes led to the discovery of a gene encoding an indolmycin-resistant isoform of tryptophanyl-tRNA synthetase. Overexpression of this gene in an indolmycin-sensitive strain increased the indolmycin MIC 60-fold. Its transcription and distribution in various bacterial genera were assessed. The level of resistance conferred by this gene was compared to that of a known indolmycin resistance gene and to those of genes with resistance-conferring point mutations.


James J Vecchione, Jason K Sello. A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin. Antimicrobial agents and chemotherapy. 2009 Sep;53(9):3972-80

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PMID: 19546369

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