Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

The most practical synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material. This review intends to focus on chemical transformations of morphinans which resulted in morphinandiene derivatives with well-established and novel pharmacological potencies. These chemical transformations were mainly associated with the formation and substitution of the unique diene structure of the ring C of the morphinan backbone.


Sándor Berényi, Csaba Csutorás, Attila Sipos. Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets. Current medicinal chemistry. 2009;16(25):3215-42

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 19548872

View Full Text