Effect of lantibiotic warnerin on lipid bilayer membranes].

M P Borisova, V P Korobov, L M Lemkina, N V Pan'kova, G N Likhatskaia

Biofizika 2009 May-Jun

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The effect of the lantibiotic warnerin on the ionic permeability of artificial membranes has been studied. Membranes were composed of different lipid fractions, including lipids isolated from warnerin-sensitive cells of Staphylococcus epidermidis. It was shown that warnerin selectively interacts with artificial membranes of different lipid composition, which leads, in some cases, to the formation of ionic channels. A computer model of the spatial structure of warnerin has been coustructed, which supports a high probability of the membranotropic activity of this peptide.

Citation

M P Borisova, V P Korobov, L M Lemkina, N V Pan'kova, G N Likhatskaia. Effect of lantibiotic warnerin on lipid bilayer membranes]. Biofizika. 2009 May-Jun;54(3):454-8