The role of latent virus infection of the central nervous system in acute hemorrhagic stroke].

A E Kul'chikov, N S Kositsyn, A N Makarenko, I G Vasil'eva

Voprosy virusologii 2009 Jul-Aug

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The purpose of the investigation was to study whether latent virus infection may activate in the murine brain using a model of hemorrhagic stroke. Acute intracerebral hemorrhagic stroke was induced in the internal capsule in accordance with the original technology. For experimental reproduction of virus meningoencephalitis, albino mice were infected with a sublethal dose of herpes simplex virus. The investigation ascertained persistent virus activation, as shown by the polymerase chain reaction technique that detected herpes simplex virus type 1 in the blood and brain of the animals, as well as the development of a cerebral inflammatory lesion associated with acute hemorrhagic stroke. The findings suggest that encephalitis may develop in acute stroke due to herpes simplex virus reactivation from the latent state, which will improve monitoring and treatment quality in acute stroke.

Citation

A E Kul'chikov, N S Kositsyn, A N Makarenko, I G Vasil'eva. The role of latent virus infection of the central nervous system in acute hemorrhagic stroke]. Voprosy virusologii. 2009 Jul-Aug;54(4):23-7