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By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and inhibitor-screening.


Lihua Peng, Guanxin Zhang, Deqing Zhang, Junfeng Xiang, Rui Zhao, Yilin Wang, Daoben Zhu. A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening. Organic letters. 2009 Sep 3;11(17):4014-7

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PMID: 19708709

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