A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening.

Lihua Peng, Guanxin Zhang, Deqing Zhang, Junfeng Xiang, Rui Zhao, Yilin Wang, Daoben Zhu

Beijing National Laboratory for Molecular Sciences, Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Organic letters 2009 Sep 3

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By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and inhibitor-screening.

Citation

Lihua Peng, Guanxin Zhang, Deqing Zhang, Junfeng Xiang, Rui Zhao, Yilin Wang, Daoben Zhu. A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening. Organic letters. 2009 Sep 3;11(17):4014-7