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Some advanced cancer patients suffer from pungent sulfury malodor. To determine the chemical identity of the odorant, we performed gas chromatography-mass spectrometry-olfactometry analysis of volatiles from fungating cancer wounds. We identified the source of the characteristic smell as dimethyl trisulfide, a compound that is known to be emitted from some vegetables and microorganisms. Controlling the production of dimethyl trisulfide should improve quality of life of patients.

Citation

Mika Shirasu, Shunji Nagai, Ryuichi Hayashi, Atsushi Ochiai, Kazushige Touhara. Dimethyl trisulfide as a characteristic odor associated with fungating cancer wounds. Bioscience, biotechnology, and biochemistry. 2009 Sep;73(9):2117-20

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PMID: 19734656

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