Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.

Güliz Gürel, Gregor Blaha, Thomas A Steitz, Peter B Moore

Department of Chemistry, Yale University, New Haven, CT 06520, USA.

Antimicrobial agents and chemotherapy 2009 Dec

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Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.

Citation

Güliz Gürel, Gregor Blaha, Thomas A Steitz, Peter B Moore. Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui. Antimicrobial agents and chemotherapy. 2009 Dec;53(12):5010-4