Antineoplastic effect of koumine in mice bearing H22 solid tumor].

Jing Cai, Lin-sheng Lei, De-biao Chi

College of Pharmacy, Southern Medical University, Guangzhou, China.

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2009 Sep

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To investigate the antitumor effects of koumine in mice bearing H22 solid tumor and its effect on the immune system of the mice. The changes in spleen and tumor weights and blood cell count were observed after koumine treatment in BALB/c athymic mice bearing H22 solid tumor, using normal saline solution and 5-Fu as the controls. Koumine significantly inhibited the tumor growth in a dose-dependent manner. The spleen index and blood cell counts in koumine group showed no significant differences from those in the saline control group, but higher than those in 5-Fu group. Koumine can significantly inhibit the growth of H22 solid tumor without obvious inhibitory effect on the immune system in mice.

Citation

Jing Cai, Lin-sheng Lei, De-biao Chi. Antineoplastic effect of koumine in mice bearing H22 solid tumor]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2009 Sep;29(9):1851-2