Acromegaly associated with gangliocytoma.

R K Crowley, Y Al-Derazi, K Lynch, D Rawluk, C J Thompson, M Farrell, A Agha

Academic Department of Endocrinology, Beaumont Hospital, Dublin 9, Ireland. rachelcrowley@hotmail.com

Irish journal of medical science 2012 Sep

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Acromegaly secondary to growth hormone-releasing hormone (GHRH) excess is rare. We report two patients with acromegaly who were diagnosed with sellar gangliocytomas that were immunopositive for GHRH. Tumour tissue persisted after debulking surgery and in the second case this was associated with persistent growth hormone hypersecretion, successfully suppressed by a somatostatin analogue. The development of functional pituitary adenomas in association with sellar gangliocytomas is poorly understood. We present a brief discussion of the possible aetiology of these unusual pituitary tumours.

Citation

R K Crowley, Y Al-Derazi, K Lynch, D Rawluk, C J Thompson, M Farrell, A Agha. Acromegaly associated with gangliocytoma. Irish journal of medical science. 2012 Sep;181(3):353-5