Lung surfactant proteins A and D as pattern recognition proteins.

Patrick Waters, Mudit Vaid, Uday Kishore, Taruna Madan

Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

Advances in experimental medicine and biology 2009

filter terms:

Lung surfactant proteins A and D belong to a group of soluble humoral pattern recognition receptors, called collectins, which modulate the immune response to microorganisms. They bind essential carbohydrate and lipid antigens found on the surface of microorganisms via low affinity C-type lectin domains and regulate the host's response by binding to immune cell surface receptors. They form multimeric structures that bind, agglutinate, opsonise and neutralize many different pathogenic microorganisms including bacteria, yeast, fungi and viruses. They modulate the uptake of these microorganisms by phagocytic cells as well as both the inflammatory and the adaptive immune responses. Recent data have also highlighted their involvement in clearance of apoptotic cells, hypersensitivity and a number of lung diseases.

Citation

Patrick Waters, Mudit Vaid, Uday Kishore, Taruna Madan. Lung surfactant proteins A and D as pattern recognition proteins. Advances in experimental medicine and biology. 2009;653:74-97