Abnormal distribution of dendritic cells in (NZW x BXSB)F1 mice.

First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan.

Autoimmunity 2009 Aug

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NZW x BXSB)F1 mice (W/BF1 mice) have been reported to develop autoimmune diseases with aging. We have also reported that the number of dendritic cells (DCs) increases in the various organs, and that the B-cell response to LPS or interleukin-4 plus anti-mu increase with aging in W/BF1 mice. In the present experiment, we show that many DCs exist not only in the T-cell area but also in the B-cell area and the sinus in the spleen of aged W/BF1 mice, and that the coculturing of DCs from aged W/BF1 mice and B cells from disease-free young W/BF1 mice produces much more IgG and IgM than normal mice. These results suggest that an abnormal distribution of DCs and the interaction of DCs and B cells induce the hyperproduction of immunoglobulin in aged W/BF1 mice.

Citation

Yoko Tokuyama, Yasushi Adachi, Keizo Minamino, Hiroshi Shintaku, Mitsuhiko Okigaki, Kumi Hayashi, Aiko Kitajima, Takashi Takaki, Naoko Koike, Chieko Shima, Yuichiro Imai, Ming Shi, Seiji Yanai, Susumu Ikehara. Abnormal distribution of dendritic cells in (NZW x BXSB)F1 mice. Autoimmunity. 2009 Aug;42(5):399-405