The dosage compensation complex shapes the conformation of the X chromosome in Drosophila.

Adolf-Butenandt-Institute and Centre for Integrated Protein Science (CiPSM), Ludwig-Maximilians-University, 80336 Munich, Germany.

Genes & development 2009 Nov 1

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The dosage compensation complex (DCC) in Drosophila globally increases transcription from the X chromosome in males to compensate for its monosomy. We discovered a male-specific conformation of the X chromosome that depends on the associations of high-affinity binding sites (HAS) of the DCC. The core DCC subunits MSL1-MSL2 are responsible for this male-specific organization. Contrary to emerging concepts, we found that neither DCC assembly nor the conformation of the male X chromosome are influenced by nuclear pore components. We propose that nuclear organization of HAS is central to the faithful distribution of the DCC along the X chromosome.

Citation

Charlotte Grimaud, Peter B Becker. The dosage compensation complex shapes the conformation of the X chromosome in Drosophila. Genes & development. 2009 Nov 1;23(21):2490-5