Boc groups as protectors and directors for Ir-catalyzed C-H borylation of heterocycles.

Venkata A Kallepalli, Feng Shi, Sulagna Paul, Edith N Onyeozili, Robert E Maleczka, Milton R Smith

Department of Chemistry, Michigan State University, East Lansing, Michigan 48824-1322, USA.

The Journal of organic chemistry 2009 Dec 4

filter terms:

Ir-catalyzed C-H borylation is found to be compatible with Boc protecting groups. Thus, pyrroles, indoles, and azaindoles can be selectively functionalized at C-H positions beta to N. The Boc group can be removed on thermolysis or left intact during subsequent transformations.

Citation

Venkata A Kallepalli, Feng Shi, Sulagna Paul, Edith N Onyeozili, Robert E Maleczka, Milton R Smith. Boc groups as protectors and directors for Ir-catalyzed C-H borylation of heterocycles. The Journal of organic chemistry. 2009 Dec 4;74(23):9199-201