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We used combinations of taxan-based neoadjuvant and adjuvant full-dose chemotherapy and aggressive combined radiotherapy including clinical target volume extension, increased total dosage, hyperthermia, cryo- and local chemotherapy as radiosensitizers, for treatment of invasive and locally-advanced breast cancer or endometrial carcinoma with poor prognosis. 3D-ultrasound/CT/MRI--based designing of radiotherapy and monitoring of dynamic definition of target volume and "high risk volume" in organs at risk in cases of tumor progression was an indispensable measure. As a result, no local recurrence was reported in 73% for 36 months.

Citation

V A Titova, N V Kharchenko, N Iu Dobrovol'skaia, Iu M Kreĭnina. Current strategies in radiotherapy for cervical and endometrial carcinoma]. Voprosy onkologii. 2009;55(4):471-3

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PMID: 19947373

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