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Enantioselective total synthesis of (-)-(S)-stepholidine.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
The Journal of organic chemistry 2009 Dec 4Sizes of these terms reflect their relevance to your search.
Enantioselective total synthesis of (-)-(S)-stepholidine, a drug candidate for the treatment of schizophrenia and/or drug abuse, is described. Asymmetric transfer hydrogenation of imines with use of Noyori's catalyst was used as the key step and (-)-(S)-stepholidine was synthesized in 6 steps, with 42% overall yield and >99% ee.
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Jian-Jun Cheng, Yu-She Yang. Enantioselective total synthesis of (-)-(S)-stepholidine. The Journal of organic chemistry. 2009 Dec 4;74(23):9225-8
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PMID: 19950885
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