To be gammadelta or not to be gammadelta? Signaling pathways in alphabeta versus gammadelta T cell maturation.

Julia K Archbold

Science signaling 2009 Dec 8

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Maturation of T cells in the thymus involves input from a number of signaling pathways; their combined input determines whether thymic precursor cells will differentiate into mature alphabeta or gammadelta T cells. This Journal Club article highlights recent research showing that the role of Notch signaling in human T cell maturation differs from that in mice. In mice, reducing Notch gene dosage in vivo promotes gammadelta T cell differentiation. In humans, an increase in Notch activity early in development will trigger gammadelta T cell development. This research emphasizes how the molecular events controlling T cell development are fundamentally different in humans and mice.

Citation

Julia K Archbold. To be gammadelta or not to be gammadelta? Signaling pathways in alphabeta versus gammadelta T cell maturation. Science signaling. 2009 Dec 8;2(100):jc2