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Total synthesis of the anti-apoptotic agents iso- and bongkrekic acids.
Antoine Francais, Antonio Leyva, Gorka Etxebarria-Jardi, Steven V Ley
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Organic letters 2010 Jan 15Sizes of these terms reflect their relevance to your search.
The first convergent total synthesis of isobongkrekic acid is reported involving three different stereospecific palladium cross-couplings for the formation of the diene units. Access to bongkrekic acid by this route is also demonstrated. These syntheses involve the formation of several potentially general building blocks.
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Antoine Francais, Antonio Leyva, Gorka Etxebarria-Jardi, Steven V Ley. Total synthesis of the anti-apoptotic agents iso- and bongkrekic acids. Organic letters. 2010 Jan 15;12(2):340-3
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PMID: 20014782
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