Transmitting the message: intracellular mRNA localization.

Carine Meignin, Ilan Davis

Department of Biochemistry, New Biochemistry Building, The University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

Current opinion in cell biology 2010 Feb

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The intracellular localization of mRNA is an important mechanism for targeting proteins to their sites of function. Localized transcripts play key roles ranging from body axis determination to synapse plasticity, and recent studies highlight how common localized transcripts are in a variety of model organisms. In this review, we consider the full range of known mechanisms for delivering transcripts and anchoring them at their site of function. Finally, we evaluate the progress that has been made in the nervous system in understanding the mechanism and function of mRNA localization and translation regulation. Copyright 2009 Elsevier Ltd. All rights reserved.