Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats.

V M Chandrashekhar, V L Ranpariya, S Ganapaty, A Parashar, A A Muchandi

Department of Pharmacology, Hanagal Shri Kumareshawr College of Pharmacy, BVVS campus, Bagalkot-587101, Karnataka, India. chandupharm@yahoo.com

Journal of ethnopharmacology 2010 Feb 17

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Traditionally, the whole plant is used for various diseases, including neuronal disorders. To evaluate the neuroprotective effect of Matricaria recutita L. against global cerebral ischemia/reperfusion (I/R) injury-induced oxidative stress in rats. Neuroprotective activity was carried out by global cerebral ischemia on Sprague-Dawley rats by bilateral carotid artery (BCA) occlusion for 30 min followed by 60 min reperfusion. The antioxidant enzymatic and non-enzymatic levels were estimated along with cerebral infarction area and histopathological studies. The Matricaria recutita L. methanolic extract showed dose-dependent neuroprotective activity by significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiol levels in extract treated groups as compared to ischemia/reperfusion group. Cerebral infarction area was significantly reduced in extract treated groups as compared to ischemia/reperfusion group. The methanolic extract of Matricaria recutita L. showed potent neuroprotective activity against global cerebral ischemia/reperfusion injury-induced oxidative stress in rats. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

Citation

V M Chandrashekhar, V L Ranpariya, S Ganapaty, A Parashar, A A Muchandi. Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats. Journal of ethnopharmacology. 2010 Feb 17;127(3):645-51