Xiao-Hui Yan, Jia Chen, Ying-Tong Di, Xin Fang, Jia-Hong Dong, Peng Sang, Yue-Hu Wang, Hong-Ping He, Zhong-Kai Zhang, Xiao-Jiang Hao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Journal of agricultural and food chemistry 2010 Feb 10Two new quassinoids, javanicolide E (1) and javanicolide F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr. The antitobacco mosaic virus (TMV) activity of these quassinoids was screened by the conventional half-leaf and leaf-disk method along with Western blot analysis. All of the seventeen quassinoids showed potent anti-TMV activity. Among them, eight compounds, brusatol (3), bruceine B (4), bruceoside B (5), yadanzioside I (6), yadanzioside L (7), bruceine D (8), yadanziolide A (9), and aglycone of yadanziolide D (17), showed strong antiviral activities, with IC(50) values in the range of 3.42-5.66 microM, and were much more effective than the positive control, ningnanmycin (IC(50) = 117.3 microM). The antiviral structure-activity relationships of quassinoids against TMV were also discussed.
Xiao-Hui Yan, Jia Chen, Ying-Tong Di, Xin Fang, Jia-Hong Dong, Peng Sang, Yue-Hu Wang, Hong-Ping He, Zhong-Kai Zhang, Xiao-Jiang Hao. Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. Journal of agricultural and food chemistry. 2010 Feb 10;58(3):1572-7
PMID: 20050684
View Full Text