Mesenchymal stem cells and bovine bone mineral in sinus lift procedures--an experimental study in sheep.

Sebastian Sauerbier, Kerstin Stubbe, Michele Maglione, Jörg Haberstroh, Jens Kuschnierz, Toshiyuki Oshima, Samuel Porfirio Xavier, Leo Brunnberg, Rainer Schmelzeisen, Ralf Gutwald

Department of Oral and Maxillofacial Surgery, Albert-Ludwigs-University, Freiburg, Germany. sebastian.sauerbier@uniklinik-freiburg.de

Tissue engineering. Part C, Methods 2010 Oct

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New reconstructive and less invasive methods have been searched to optimize bone formation and osseointegration of dental implants in maxillary sinus augmentation. The aim of the presented ovine split-mouth study was to compare bovine bone mineral (BBM) alone and in combination with mesenchymal stem cells (MSCs) regarding their potential in sinus augmentation. Bilateral sinus floor augmentations were performed in six adult sheep. BBM and MSCs were placed into the test side and only BBM in the contra-lateral control side of each sheep. Animals were sacrificed after 8 and 16 weeks. Augmentation sites were analyzed by computed tomography, histology, and histomorphometry. The initial volumes of both sides were similar and did not change significantly with time. A tight connection between the particles of BBM and the new bone was observed histologically. Bone formation was significantly (p = 0.027) faster by 49% in the test sides. The combination of BBM and MSCs accelerated new bone formation in this model of maxillary sinus augmentation. This could allow early placement of implants.

Citation

Sebastian Sauerbier, Kerstin Stubbe, Michele Maglione, Jörg Haberstroh, Jens Kuschnierz, Toshiyuki Oshima, Samuel Porfirio Xavier, Leo Brunnberg, Rainer Schmelzeisen, Ralf Gutwald. Mesenchymal stem cells and bovine bone mineral in sinus lift procedures--an experimental study in sheep. Tissue engineering. Part C, Methods. 2010 Oct;16(5):1033-9