Suppressive effects of a cyanine dye against herpes simplex virus (HSV)-1 infection.

Chie Ushio, Harumi Ariyasu, Toshio Ariyasu, Shigeyuki Arai, Tsunetaka Ohta, Shigeharu Fukuda

Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan. fujisaki@hayashibara.co.jp

Biomedical research (Tokyo, Japan) 2009 Dec

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In this study, we demonstrate that a cyanine dye, lumin, significantly suppressed cytopathic effect by herpes simplex virus (HSV)-1 toward human amnionic FL cell and also it reduced replication of HSV-1 in a dose-dependent manner. In addition, lumin additively augmented the antiviral effect of interferon (IFN)-alpha. Furthermore, fluorescence microscopic study showed that lumin (not IFN-alpha) itself remarkably induced alkalinization of intracellular organelle, suggesting the inhibition of virus invasion into the cells. These results suggest that lumin exerts an antiviral action against HSV-1 with the independent pathways of IFN-alpha and also it would become a therapeutically effective drug in clinical practice.

Citation

Chie Ushio, Harumi Ariyasu, Toshio Ariyasu, Shigeyuki Arai, Tsunetaka Ohta, Shigeharu Fukuda. Suppressive effects of a cyanine dye against herpes simplex virus (HSV)-1 infection. Biomedical research (Tokyo, Japan). 2009 Dec;30(6):365-8