Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033.
Kazuro Shiomi, Ryosuke Matsui, Atsuo Kakei, Yuichi Yamaguchi, Rokuro Masuma, Hiroko Hatano, Noriko Arai, Miki Isozaki, Haruo Tanaka, Susumu Kobayashi, Andreas Turberg, Satoshi Omura
Kitasato Institute for Life Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan. shiomi@lisci.kitasato-u.ac.jp
The Journal of antibiotics 2010 FebA new ryanodine-binding inhibitor, verticilide, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1033. It is a 24-membered ring cyclic depsipeptide, its structure being elucidated as cyclo[(2R)-2-hydroxyheptanoyl-N-methyl- L-alanyl](4). Verticilide inhibited ryanodine binding to ryanodine receptors in the cockroach at an IC(50) value of 4.2 microM, whereas inhibition against mouse ryanodine receptors was weak (IC(50)=53.9 microM).
Citation
Kazuro Shiomi, Ryosuke Matsui, Atsuo Kakei, Yuichi Yamaguchi, Rokuro Masuma, Hiroko Hatano, Noriko Arai, Miki Isozaki, Haruo Tanaka, Susumu Kobayashi, Andreas Turberg, Satoshi Omura. Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033. The Journal of antibiotics. 2010 Feb;63(2):77-82
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PMID: 20057513
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