Programming DNA replication origins and chromosome organization.

Christelle Cayrou, Philippe Coulombe, Marcel Méchali

Institute of Human Genetics, CNRS, 141 Rue de la Cardonille, 34980 Montpellier, France.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2010 Jan

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During each cell cycle, thousands of DNA replication origins are activated in each cell of a metazoan organism. Although they appear site-specific, their usage and organization are rather plastic. Moreover, no strict sequence specificity has been observed in contrast to bacterial or Saccharomyces cerevisiae DNA replication origins. Epigenetic regulation linked to chromatin structure, chromosome organization, and transcription has been suggested to explain how DNA replication origins are selected and recognized by replication initiation factors. In this paper, we review these epigenetic features and discuss how, during the previous mitosis, chromosomal architecture might prepare DNA replication origins for a new cell cycle.

Citation

Christelle Cayrou, Philippe Coulombe, Marcel Méchali. Programming DNA replication origins and chromosome organization. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 2010 Jan;18(1):137-45