Effects of scoparone on dopamine release in PC12 cells.

Yoo Jung Yang, Hak Ju Lee, Byung Koo Lee, Sung Cil Lim, Chong Kil Lee, Myung Koo Lee

College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University, Cheongju 361-763, Republic of Korea.

Fitoterapia 2010 Sep

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The effects of scoparone on dopa mine release in PC12 cells were investigated. Scoparone at 50-200 microM increased dopamine release into the culture medium. However, the released levels of dopamine by scoparone were not altered in the absence of extracellular Ca(2+) and by adenylyl cyclase inhibitor MDL-12,330A. Scoparone increased phosphorylation of PKA, CaMK II and synapsin I. Scoparone also enhanced K(+)-induced levels of dopamine release by CaMK II phosphorylation. These results suggest that scoparone increases dopamine release by synapsin I phosphorylation via activation of PKA and CaMK II, which are mediated by cyclic AMP levels and Ca(2+) influx. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Citation

Yoo Jung Yang, Hak Ju Lee, Byung Koo Lee, Sung Cil Lim, Chong Kil Lee, Myung Koo Lee. Effects of scoparone on dopamine release in PC12 cells. Fitoterapia. 2010 Sep;81(6):497-502