Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging.

Eun Jung Kim, Su Hee Hong, Tae Hyun Choi, Eun Ah Lee, Kyeong Min Kim, Kyo Chul Lee, Gwang Il An, Mohammed I El-Gamal, Gi Jeong Cheon, Chang Woon Choi, Sang Moo Lim

Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2010 Jun

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The goal of this investigation was to evaluate the effects of structural differences between FIAU and FIRU on their ability to serve as a potential tracer for reporter gene imaging. To examine the characteristics of different configurations of FIAU and FIRU, a series of evaluations were done on HSV1-TK gene-expressing cells and on mice with HSV1-TK gene-expressing tumor. The results showed that, as an imaging agent for HSV1-TK-expressing cells, radiolabeled FIAU was more efficient for in vivo imaging than FIRU. Copyright 2009 Elsevier Ltd. All rights reserved.

Citation

Eun Jung Kim, Su Hee Hong, Tae Hyun Choi, Eun Ah Lee, Kyeong Min Kim, Kyo Chul Lee, Gwang Il An, Mohammed I El-Gamal, Gi Jeong Cheon, Chang Woon Choi, Sang Moo Lim. Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2010 Jun;68(6):971-8