Associations between XPD polymorphisms and risk of breast cancer: a meta-analysis.

Zheng Jiang, Chunxiang Li, Ye Xu, Sanjun Cai, Xishan Wang

Department of Colorectal Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China.

Breast cancer research and treatment 2010 Aug

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Studies on polymorphisms of Xeroderma Pigmentosum Group D Protein (XPD) and breast cancer risk are inconclusive. To elucidate the role of XPD genotypes, all available studies were considered in this meta-analysis. The study provided 11,362/10,622 cases/controls for XPD K751Q and 9010/9873 cases/controls for XPD D312N, respectively. Overall, no apparent effects of 751Q allele compared to 751K on breast cancer risk was found in all subjects [RE OR = 1.04, 95% confidence interval (CI) (0.97-1.10), P = 0.28]. Insignificant effects were also found under other genetic contrasts (homologous contrast, dominant model, and recessive model). However, the 751Q allele showed significantly increased risk in Caucasians [FE OR = 1.05, 95% CI (1.00-1.11), P = 0.035]. In addition, insignificant risk effects of D312N polymorphism on breast cancer susceptibility were observed in all subjects under any genetic contrast, but protective effects of 312NN genotype were observed under recessive model [P = 0.02, OR = 0.53, 95% CI (0.32, 0.90)] and homozygote contrast [P = 0.03, OR = 0.55; 95% CI (0.32, 0.96)] in Asians. In summary, our meta-analysis suggested 312N allele might act as a recessive allele in its association with breast cancer and the 751Q allele may play a plausible role in breast cancer development whereas the ethnic background should be carefully concerned in further studies.

Citation

Zheng Jiang, Chunxiang Li, Ye Xu, Sanjun Cai, Xishan Wang. Associations between XPD polymorphisms and risk of breast cancer: a meta-analysis. Breast cancer research and treatment. 2010 Aug;123(1):203-12