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We report the artifactual elevation of homogentisic acid (HGA) in urine from alkaptonuric patients after replacing the creatinine method (Jaffe reaction) in our laboratory with an automated enzymatic method. Samples with elevated HGA by GC-MS had lower creatinine values as determined by the enzymatic method than by the Jaffe reaction. The low creatinine values were due to interference by HGA in the enzymatic method. The enzymatic method is unsuitable for creatinine determination in urine of patients with alkaptonuria. (c) 2010 Elsevier Inc. All rights reserved.


Perry R Loken, Mark J Magera, Wendy Introne, Silvia Tortorelli, Dimitar Gavrilov, Devin Oglesbee, Piero Rinaldo, Dietrich Matern, Kimiyo Raymond. Homogentisic acid interference in routine urine creatinine determination. Molecular genetics and metabolism. 2010 May;100(1):103-4

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PMID: 20138792

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