Rol of pituitary tumour-transforming gene (PTTG) in the pituitary adenomas].

Ruth Sánchez-Ortiga, Laura Sánchez Tejada, Gloria Peiró Cabrera, Oscar Moreno-Pérez, Nieves Arias Mendoza, F Ignacio Aranda López, Antonio Picó Alfonso

Sección de Endocrinología y Nutrición, Hospital General Universitario de Alicante, Alicante, España.

Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición 2010 Jan

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The pathogenesis of pituitary tumours is far to be understood. Pituitary transforming tumour gene (PTTG), a gen that induces aneuploidy, genetic instability, cellular proliferation and to stimulate angiogenesis, has been involved in neoplasic transformation and shown overexpressed in many neoplasm as lung, breast, endometrium, thyroid and colon malignant tumours. On the other hand, PTTG has been inconsistently studied in pituitary tumours. The majority of studies have been performed in animals and there is a great variability in the methods used in its determination. The goal of this review is to resume the role of PTTG in tumourogenesis and critically to revise the studies published in humans in order to advance in the knowledge of the pathogenesis of pituitary adenomas and to find clinical useful predictors of the behavior of these tumours. Copyright 2010 Sociedad Española de Endocrinología y Nutrición. Published by Elsevier Espana. All rights reserved.

Citation

Ruth Sánchez-Ortiga, Laura Sánchez Tejada, Gloria Peiró Cabrera, Oscar Moreno-Pérez, Nieves Arias Mendoza, F Ignacio Aranda López, Antonio Picó Alfonso. Rol of pituitary tumour-transforming gene (PTTG) in the pituitary adenomas]. Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición. 2010 Jan;57(1):28-34