Attenuation of experimental murine colitis by acanthoic acid from Acanthopanax koreanum.

Ok-Hwa Kang, Dae-Ki Kim, Xing-Fu Cai, Young-Ho Kim, Young-Mi Lee

Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute, Iksan 570-749, Korea.

Archives of pharmacal research 2010 Jan

filter terms:

Acanthoic acid (AA) is a pimaradiene diterpene isolated from Acanthopanax koreanum. We examined the effect of AA in dextran sulfate sodium (DSS)-induced colitis. AA (100 mg/kg or 300 mg/kg) was administered p.o. daily for 7 days. AA significantly inhibited Disease Activity Index, histological score, and myeloperoxidase activity. Furthermore, AA markedly suppressed the protein expression of TNF-alpha, COX-2, NF-kappaB and chymase as well as the mRNA expression of TNF-alpha and COX-2. These results suggest that AA exerts beneficial effects in experimental colitis, and therefore we propose that this compound may have therapeutic implications for ulcerative colitis.

Citation

Ok-Hwa Kang, Dae-Ki Kim, Xing-Fu Cai, Young-Ho Kim, Young-Mi Lee. Attenuation of experimental murine colitis by acanthoic acid from Acanthopanax koreanum. Archives of pharmacal research. 2010 Jan;33(1):87-93