Modification of polyglutamic acid with silanol groups and calcium salts to induce calcification in a simulated body fluid.

Mi-Young Koh, Chikara Ohtsuki, Toshiki Miyazaki

Graduate School of Engineering, Nagoya University, Furo-cho Chikusa-ku, Nagoya 464-8603, Japan. koh.miyoung@h.mbox.nagoya-u.ac.jp

Journal of biomaterials applications 2011 Feb

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The formation of hydroxyapatite is important for artificial materials to show high biological affinities for bone tissue. The present study focused on the synthesis of hydrogels capable of showing apatite formation, through modification of polyglutamic acid (PGA) with 3-aminopropyltriethoxysilane (APTES), followed by treatment with calcium chloride solution. A transparent bulk hydrogel was obtained at a molar ratio of PGA/APTES of 0.5. Prior soaking of the PGA hydrogel in calcium chloride solution accelerated the formation of bone-like apatite in a simulated body fluid. The modified PGA hydrogel is a candidate material for a biodegradable scaffold for bone regeneration.

Citation

Mi-Young Koh, Chikara Ohtsuki, Toshiki Miyazaki. Modification of polyglutamic acid with silanol groups and calcium salts to induce calcification in a simulated body fluid. Journal of biomaterials applications. 2011 Feb;25(6):581-94