Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain.

Analytical interference in laboratory assays is not only unpredictable but also an underestimated problem. Not recognising these interferences can lead to misdiagnosis and mismanagement of patients. We present a case of a patient with chest pain and ischaemic risk factors with incongruent biochemical results. These results were discovered to be due to the presence of macro-creatine kinase (macro-CK) in vivo interfering with the CKMB activity assay.

Citation

D Schulenburg, W De Lange, H Van Jaarsveld, J M Kuyl. Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain. Cardiovascular journal of Africa. 2010 Jan-Feb;21(1):47-8

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PMID: 20224846

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