Activity of glucose-6-phosphate metabolism enzymes in the livers of rats with experimental valekson poisoning].

U A Kuz'minskaia, L V Bersan, M V Pis'mennaia

Biulleten' eksperimental'noĭ biologii i meditsiny 1977 Dec

filter terms:

The activity of hexokinase, glucose-6-phosphatase and glucose-6-phosphoric dehydrogenase was studied in the liver of rats after one hour, one and five days after a single oral administration of organic phosphorus insecticide valekson. It was determined that administration of the preparation led to an increase of activity in the homogenate and solubilization of glucose-6-phosphatase, activation of glucose-6-phosphoric dehydrogenase and inhibition of hexokinase. The changes were maximum one hour after the administration of the compound. The results show that a decrease of the intensity of glucose-6-phosphate formation and metabolism is one of the pathogenetic factors in the development of valekson-induced intoxication.

Citation

U A Kuz'minskaia, L V Bersan, M V Pis'mennaia. Activity of glucose-6-phosphate metabolism enzymes in the livers of rats with experimental valekson poisoning]. Biulleten' eksperimental'noĭ biologii i meditsiny. 1977 Dec;84(12):677-9