Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy.

Serhiy Havrylov, Maria Jolanta Redowicz, Vladimir L Buchman

Nencki Institute of Experimental Biology, Pasteura 3 Street, 02-093 Warsaw, Poland.

Traffic (Copenhagen, Denmark) 2010 Jun

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Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle-mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti-cancer therapies.

Citation

Serhiy Havrylov, Maria Jolanta Redowicz, Vladimir L Buchman. Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy. Traffic (Copenhagen, Denmark). 2010 Jun;11(6):721-31