Regulation of telomerase activity by apparently opposing elements.

Jun-Ping Liu, Shi-Ming Chen, Yu-Sheng Cong, Craig Nicholls, Shu-Feng Zhou, Ze-Zhang Tao, He Li

Molecular Signaling Laboratory, Department of Immunology, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct (AMREP), Commercial Road, Melbourne, Victoria 3004, Australia.

Ageing research reviews 2010 Jul

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Telomeres, the ends of chromosomes, undergo frequent remodeling events that are important in cell development, proliferation and differentiation, and neoplastic immortalization. It is not known how the cellular environment influences telomere remodeling, stability, and lengthening or shortening. Telomerase is a ribonucleoprotein complex that maintains and lengthens telomeres in the majority of cancers. Recent studies indicate that a number of factors, including hormones, cytokines, ligands of nuclear receptor, vitamins and herbal extracts have significantly influence telomerase activity and, in some instances, the remodeling of telomeres. This review summarizes the advances in understanding of the positive and negative regulation by extracellular factors of telomerase activity in cancer, stem cells and other systems in mammals. 2010 Elsevier Ireland Ltd. All rights reserved.

Citation

Jun-Ping Liu, Shi-Ming Chen, Yu-Sheng Cong, Craig Nicholls, Shu-Feng Zhou, Ze-Zhang Tao, He Li. Regulation of telomerase activity by apparently opposing elements. Ageing research reviews. 2010 Jul;9(3):245-56