Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men.

Tomoko Yokoyama, Takashi Usui, Kazuhiro Kiyama, Ran Nakashima, Naoichiro Yukawa, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takao Fujii, Tsuneyo Mimori

Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Modern rheumatology / the Japan Rheumatism Association 2010 Aug

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We have experienced two cases of drug-induced lupus erythematosus caused by ticlopidine in the last three years. Both were late-onset cases (1 and 4 years) that occurred in elderly men (76 and 81 years old). The common features were fever, arthralgia, myalgia, serositis, and the presence of anti-histone autoantibodies. Because ticlopidine is widely used in elderly people with ischemic vascular disease, ticlopidine-induced lupus should be considered when patients taking ticlopidine present lupus-like symptoms.

Citation

Tomoko Yokoyama, Takashi Usui, Kazuhiro Kiyama, Ran Nakashima, Naoichiro Yukawa, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takao Fujii, Tsuneyo Mimori. Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men. Modern rheumatology / the Japan Rheumatism Association. 2010 Aug;20(4):405-9