Combination of electrochemical, spectrometric and other analytical techniques for high throughput screening of pharmaceutically active compounds.

Recently, use of electrochemistry and combination of this method with spectroscopic and other analytical techniques are getting one of the important approaches in drug discovery and research as well as quality control, drug stability, determination of physiological activity, measurement of neurotransmitters. Many fundamental physiological processes are depending on oxido-reduction reactions in the body. Therefore, it may be possible to find connections between electrochemical and biochemical reactions concerning electron transfer pathways. Applications of electrochemical techniques to redox-active drug development and studies are one of the recent interests in drug discovery. In this review, the latest developments related to the use of electrochemical techniques in drug research in order to evaluate possible combination spectrometric methods with electrochemical techniques.

Citation

Sibel Suzen, Sibel A Ozkan. Combination of electrochemical, spectrometric and other analytical techniques for high throughput screening of pharmaceutically active compounds. Combinatorial chemistry & high throughput screening. 2010 Aug;13(7):658-64

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PMID: 20402642

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