Practical tip: Precooling topical calcineurin inhibitors tube; reduces burning sensation.

College of Medicine, Division of Dermatology, Department of Medicine, King Abdulaziz Medical City, Riyadh, King Saud Bin Abdulaziz University for Health Sciences. salkhenaizan@hotmail.com

Dermatology online journal 2010

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Burning sensation at the site of application is the most common side effect of topical calcineurin inhibitors and is considered the most common reasons for premature discontinuation. Here, we analyze the possible mechanism(s) and offer a simple practical tip to mitigate this adverse effect. Simple cooling of the tube, immediately before use, does reduce the burning sensation and enable most intolerant patients to use the medication comfortably. We also discuss the possible explanation(s) for the success of this maneuver.

Citation

Sultan Al-Khenaizan. Practical tip: Precooling topical calcineurin inhibitors tube; reduces burning sensation. Dermatology online journal. 2010;16(4):16