Novoamauromine and ent-Cycloechinulin: two new diketopiperazine derivatives from Aspergillus novofumigatus.

Kazuki Ishikawa, Tomoo Hosoe, Takeshi Itabashi, Daigo Wakana, Kayoko Takizawa, Takashi Yaguchi, Ken-ichi Kawai

Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.

Chemical & pharmaceutical bulletin 2010 May

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Two new diketopiperazine metabolites, novoamauromine (1) and ent-cycloechinulin (2) have been isolated from Aspergillus novofumigatus CBS117520. The structures of 1 and 2 were established on the basis of spectroscopic and chemical investigation, including a detailed comparison of the spectroscopic and physico-chemical data of amauromine (3) and cycloechinulin (4).

Citation

Kazuki Ishikawa, Tomoo Hosoe, Takeshi Itabashi, Daigo Wakana, Kayoko Takizawa, Takashi Yaguchi, Ken-ichi Kawai. Novoamauromine and ent-Cycloechinulin: two new diketopiperazine derivatives from Aspergillus novofumigatus. Chemical & pharmaceutical bulletin. 2010 May;58(5):717-9