Hydrolysable tannins depress cardiac papillary muscle contraction and propranolol-induced negative inotropism.

Hobeom Lee, Ji Yun Lee, Moo Hyun Suh, Sang-Soo Sim, Min-Won Lee, Chang Jong Kim

Division of Pathophysiology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.

Fitoterapia 2010 Oct

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We studied effects of hydrolysable tannins on rat papillary muscle contractions induced by propranolol. The developed force of papillary muscle was measured isometrically with an inductive force transducer. The IC(50) values for digallic acid, gallic acid, germin D, praecoxin A and 1-desgalloyl rugosin F were 4.2 x 10(-5) M, 1.3 x 10(-4) M, 1,4 x 10(-4) M, 1.5 x 10(-4) and 1.7 x 10(-4) M, respectively. Incubation with tannins significantly attenuated the propranolol-induced negative inotropic contractile response. These results show that hydrolysable tannins depress muscle contractions and potentiate the activities of β-adrenergic blocker. Copyright © 2010 Elsevier B.V. All rights reserved.

Citation

Hobeom Lee, Ji Yun Lee, Moo Hyun Suh, Sang-Soo Sim, Min-Won Lee, Chang Jong Kim. Hydrolysable tannins depress cardiac papillary muscle contraction and propranolol-induced negative inotropism. Fitoterapia. 2010 Oct;81(7):820-5