Antiviral drug resistance: mechanisms and clinical implications.

Division of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, mail code L457, Portland, OR 97239, USA. strasfel@ohsu.edu

Infectious disease clinics of North America 2010 Jun

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Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of mechanisms of resistance, and the development of new antivirals. This article discusses drug resistance in herpesviruses and hepatitis B. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Citation

Lynne Strasfeld, Sunwen Chou. Antiviral drug resistance: mechanisms and clinical implications. Infectious disease clinics of North America. 2010 Jun;24(2):413-37